Allertol, The Allergy Drop Solution

Allerto The Allergy Drop SolutionAllergy Drops, Not Shots: Simple....ALLERTOL® 

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Allertol FAQS

What is an allergy?

An allergy is a immune system disorder characterized by abnormal reaction to a substance that is not expected in the average person. The concept of allergy was first introduced and defined in 1906, by a pediatrician from Vienna named von Pirquet, describing abnormal reactions to food, pollen and dust.

Why did I develop allergies?

The tendency to develop an allergy may have to do with genetics and to repeated exposure to a food or airborne substance. This can allow dander, dust mite dung, and pollen to induce an allergic response from your immune system. Research has implicated a malfunctioning FOXP3 gene, that can cause a lack of T regulatory cells (Treg). These cells induce tolerance to these foreign protein substances that are eaten or inhaled. The Treg cells also appear to be important in preventing damage from inflammation of respiratory tissue, such as in chronic asthma. Treg cells normally are produced in abundance when we eat or inhale substances; they send messages to the immune system to allow safe passage of foreign proteins. An abundance of Treg cells with properly functioning FOXP3 gene is present in those without allergies. It is hoped that further research on the FOXP3 gene will produce more functional Treg cells and thus a more tolerant immune system for the allergy sufferer.

What areas are affected, and what symptoms can occur from allergies?

An allergy can involve any part of the body. Any system. Any tissue. Most reactions involve the areas cared for by your Otolaryngologist, especially the nose, in both airborne and delayed food allergy reactions. Foods tend to cause more nasal stuffiness when the patient is lying down. Except for house dust mite feces and body parts in the pillow, and the pet that loves to lick its fur often and spend time on or in the bed or couch, airborne allergies tend to be more of a problem when the patient is up and about. Some cases of fluctuating hearing loss, dizziness and / or buzzing in the ear (Menieres) have been associated with delayed food allergy. Symptoms from delayed food allergy reactions typically occur hours after ingestion, rarely up to a day or so. Sometimes symptoms, such as sneezing, occur before the meal is finished! Common symptoms from delayed food allergy or food sensitivity include: nighttime nasal blockage, persistent runny nose, repeated sneezing, itching of the nose, eyes, and sometimes the throat, throat clearing, general headache, migraine headache, dark circles under the eyes, lower eyelid wrinkles from congestion, sinus infections, middle ear fluid and infections, skin itching, hives, eczema, cough, wheezing, nasal polyps, hyperactivity, fatigue and trouble concentrating. Delayed food allergy is a prime cause for recurrent sinus and ear infections, as well as nasal polyps.

How do sublingual drops work?

Special receptors of the floor of the mouth called “dendritic cells” detect the molecules present in the drop solution, and send messages to the immune system “T cells” to induce tolerance to these substances. These specialized T cells induce “down regulation” of the immune system, making the immune system more tolerant of the protein molecules in the allergy drop solution.

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Is Sublingual Immunotherapy FDA approved?

Yes, the FDA has approved SLIT (sublingual immunotherapy) in the form of tablets for weeds tree and grass allergies.  The FDA has approved the extracts used in sublingual immunotherapy many years ago, for skin testing and allergy shots.

Allergy shots, or subcutaneous immunotherapy (SCIT), have had high efficacy, and have been safe for most patients, with few deaths reported annually in the US. Allergy shot mortalities led the United Kingdom to essentially outlaw allergy shots, by requiring that several hours following an allergy shot, the patient be observed in a hospital setting able to provide emergency treatment for reactions to the shots.

Subsequently, there has been renewed interest in Europe for a safer modality of immunotherapy. SLIT is now widely utilized in Europe, where there have been no reports of deaths from sublingual allergy drop therapy. The FDA expects the medical practitioner to offer alternatives, after evaluating various modalities of treatment, including off-label (non FDA approved) therapy when it appears to be in the best interest of the patient.

In fact, the World Health Organization has stated that SLIT is a viable alternative to allergy shots.

Are other FDA approved products being used “off label” by doctors?

Yes. The cosmetic use of Botox is an example. Botox was originally approved by the FDA for treatment of muscle spasm. But its “off label” cosmetic use for treating facial wrinkles was commonplace, prior to its final approval by the FDA on April 15, 2002.

Does everyone get the same thing in the vial?

No. Each individual receives specific treatment depending upon history and clinical evaluation. In the case of the airborne allergy vial, results from skin testing are used to determine safe starting doses of the various pollens, molds, animal danders, and house dust mite. For example, a weak dilution of grass pollen would be used if there has been a strong reaction to the grass skin test. A stronger solution would be given for a weak test response.

In the case of the chronic delayed food allergy, a detailed history and sublingual evaluation is done to determine which particular food solutions are used.

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Can the allergy drop solution be used to treat sudden severe reactions (anaphylaxis) to a single known offending food, such as severe reactions to peanut and fish?

No. Allergy drops are not used for anaphylactic reactions to foods, just as shots are not normally recommended for this problem. If there is a history of severe, sudden anaphylactic reaction to a specific food, with symptoms such as sudden extensive hives, life-threatening asthma, and/or swelling of a part of the body, such as swelling of the mouth, tongue, or throat, then allergy drops would not be provided. The patient with a history of a sudden reaction to a known food, must strictly avoid that food, and be prepared to discover these reactions early so prompt medical attention can be delivered. It may be helpful to join one of the online food allergy networks. It is very important to inform your personal health care provider if there is a history of sudden severe food reaction, or if such reactions develop in the future, and keep up with management guidelines from the office of your healthcare provider.

What can I expect the allergy drops to do?

Allergy drops provide significant relief of symptoms in the majority of our patients, and result in less need for medications and associated medication side effects.

What alternatives do I have to treating my allergies?

You can avoid some allergens, medicate to reduce symptoms or treat the immune system. Avoidance - some allergens such as grass can be avoided by giving the lawn mowing job to someone else. Avoiding common foods such as corn can be challenging, as corn is pervasive in our diet. High fructose corn syrup, for example is common in most soft drinks, and has become a common contributor to chronic food allergy symptoms.

Medication – steroid nasal sprays, antihistamines and anti-leukotrienes can used prior to airborne allergen exposure. Medications have had a limited effect upon chronic delayed food reactions.

Immunotherapy – allergy shots, called subcutaneous immunotherapy or SCIT and allergy drops, called sublingual immunotherapy or SLIT, can be very effective.

Is it really necessary for me to avoid things to which I am allergic?

Treating delayed food allergies with the ALLERTOL®  method, elimination diets are not necessary. 

Airborne allergens are avoided as possible, especially animal dander and grass pollen, especially with asthma.

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When can I stop taking medications that I have been using to treat allergy problems?

As symptoms are relieved, you may taper off of these medications.

How long should I expect to receive the allergy drops before I am “cured”.

There is no "cure" for allergies at this time.  Sublingual immunotherapy requires up to 5 years for relief of allergy symptoms.  When symptoms are controlled, the drops are tapered from 3 / day --> 2 / day, then eventually 1 / day before immunotherapy completed.

I have been told that I have “vasomotor rhinitis”. Decongestant medications and surgery to open the nasal airways have been recommended. Could chronic food allergies be the problem?

Yes. As stated in the text “Otolaryngic Allergy”, regarding patients diagnosed with vasomotor rhinitis, “Attention should be directed toward delayed-onset food allergy…” Patients are commonly told they have vasomotor rhinitis when there is no evidence for Gell and Combs Type I IgE mediated allergy, or “atopy”. Most delayed food allergy reactions are associated with Type IV cellular immune reactions. There is currently no good skin or blood test for these delayed food allergies.

The twice patented ALLERTOL method for testing and treating delayed food allergies has been ineffective.

How long will it take before I can notice some relief of my allergy symptoms?

Airborne allergy symptoms may be reduced a by starting allergy drops at least three months before onset of the allergy season. For example, in north central Texas, starting allergy drop therapy in early January may be sufficient to reduce springtime allergy problems. Receiving the allergy drop solution throughout the year is more effective, and is recommended for the multi-season inhalant allergy patient.

Symptoms from delayed food allergens may begin to be relieved as soon as the first several days of treatment. As with the airborne allergens, continued regular use of the drops can result in steady symptom improvement.

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Does it matter if I eat around the same time I use the drops?

Yes, it does matter. The receptors of the floor of the mouth should be “primed” by avoiding chewing gum, mints, drinks, or having other food prior to placing the allergy drop solution under the tongue. You should use the drops three times a day: just after awakening from sleep, late afternoon, and upon lying down in bed prior to going to sleep.

Besides molecules of food or airborne antigens, and sterile water, what else is in the allergy drop vial?

Pure glycerin from a plant source is present in the vial, as a preservative.

Can glycerin preservative in the allergy drop solution cause a problem?

Yes, it can. Some people are sensitive to glycerin, which is a common ingredient in most toothpaste, soaps and lotions. Commercially made glycerin can come from animal (beef or pork) and / or vegetable sources. The glycerin used in the allergy drop solution is derived totally from plant sources, and not from any animal. If you know you react to glycerin-containing products, you may not be able to receive allergy drops. However, a weak allergy drop solution of glycerin can sometimes be used to treat glycerin reactions. Most people that are glycerin sensitive are aware of this because they react to almost all toothpaste, soaps, hair softeners, and lotions.

Have there been fatal reactions reported from using allergy drops or shots?

There has never been a report of death from use of allergy drops. Deaths from severe, anaphylactic allergy reaction to allergy shots do occur. Furthermore, in a 15 year literature review of allergy drop use, reported in 2007 by Dr. Leatherman from Southwestern Medical School in Dallas, there have been no life-threatening reactions reported. Millions of allergy drops have been given safely to thousands of patients.

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What are the reactions to allergy drops?

The reactions from allergy drops have typically been limited to mouth itching / swelling, tiredness, headache, eye / nose itching, nasal blockage, abdominal discomfort, nausea, hives, cough and wheezing. These uncommon symptoms may occur during the first few days of starting immunotherapy. Symptoms that occur after being established on the allergy drops are likely related to other causes, and it is best to keep a record of what was eaten and of airborne exposures prior to developing the symptom.

How is a reaction to the allergy drop treated?

If symptoms listed above develop within an hour of receiving an allergy drop, Benadryl is taken. The allergy drops are stopped, and the office notified to make an appointment for repeat evaluation.

Is there a risk of severe allergic reaction?

If there is a history of severe asthma and / or recurrent hives, there is increased risk for a severe reaction called anaphylaxis, with or without use of allergy drops. If there is a history of severe asthma, severe hives or anaphylactic allergy reaction, allergy drop therapy is not recommended.

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How often are the follow-up visits?

Regular evaluations are required every 6-12 months, sooner as needed.

How do I reorder the vials?

Contact the office.  Your vials will be ready within two business days, ready to be picked up, or mailed.  If a trip is planned, order vials early.

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What is concomitant food allergy?

Certain foods, when eaten during your allergy season, can make your allergies worse.

  Concomitant Foods
Elm milk, mint
Ragweed milk, mint, melons, banana
Marsh Elder wheat
Pigweed pork, black pepper
Posion Ivy/Oak/Sumac pork, black pepper
Cedar beef, yeast
Grass apple, carrot, celery, potato
Oak egg, apple
Cottonwood lettuce
Pecan corn, banana
Mesquite cane sugar, orange
Molds cheese, mushrooms, candida, ground molds
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Allertol is NOT used to prevent or treat immediate life-threatening allergy/anaphylaxis.

Allertol, The Allergy Drop Solution
John P. Shea, MD

Texas Health Huguley,
Medical Office Bldg 3
11797 S. FWY
Suite 132
Burleson, Texas 76028
Office Hours
Mon - Thurs
8:30am - 4:30pm
8:30am - Noon

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